Pathologic Physiology

The clinical chemistry and pathologic physiology of thyroid tissue.

THE RAPIDLY GROWING list of inborii errors of metabolism has largely defied satisfactory classification (1). Some of these disorders fall into neat biochemical analogues with no unifying clinical theme, whereas others can be grouped into anatomic pigeonholes or into schemes related to organ systems although there is not the slightest biochemical relationship. There are a few instances where ord...

Pathologic physiology of angina pectoris and acute myocardial infarction.

T HE DISTRESS or pain of angina peetoris and of acute myocardial infarction is consequent to ischemia. In angina pectoris the isehemia is transitory because of temporary disproportion between the blood supply and the myocardial requirements; in acute myocardial infaretion the ischemia is prolonged and leads to the irreversible changes of necrosis. The actual stimulus at the nerve end-organs tha...

Signs and Symptoms: Applied Pathologic Physiology and Clinical Interpretation

As for the means, morphine in quickly cumulative doses is one of the best. Insulin produces unconsciousness easily; as little as 40 units may be fatal to a cachectic patient, while others need much more. Venesection is unreliable. Relatives should be warned that the patient is worse, and is reaching unconsciousness rapidly. One other point about such treatmentthe doctor should always give the d...

The use of radioactive iodine in studying the pathologic physiology of thyroid disease.

It was in May, 1938 that Hertz et al. (1) published the first report on biological studies with a radioactive isotope of iodine. By today's standards these first studies were done under the least favorable conditions with an isotope whose half life of 25 minutes limited the studies that could be done. Notwithstanding the limitations put on these investigators they not only reaffirmed certain pr...

Tuberculosis: A Discussion of Phthisiogenesis, Immunology, Pathologic Physiology, Diagnosis and Treatment